Program Overview

Current first-line treatment of acute lymphoblastic leukemia (ALL) comprises induction, consolidation, intensification, and maintenance chemotherapy. Asparaginase is a critical component during induction, consolidation and intensification in pediatric and adult/young adult populations leading to improvements in event-free and overall survival. Yet the toxicity profile of asparaginase and drug-shortages both contribute to insufficient exposure to asparaginase and suboptimal outcomes in ALL. Appropriate management of patients with ALL is challenging, particularly for adult-focused HCPs unfamiliar with pediatric and adolescent and young adults (AYA) protocols.

This CME-certified activity will focus on minimal residual disease (MRD) considerations in the treatment of ALL. Reviewing the results of the GMALL and UKALL 2003 trials presented at ASH in 2021, participants of this activity will have the opportunity to explore the results of GMALL which used a risk-adapted, MRD-stratification for ND-ALL and LBL adult patients. The second trial discussed reviews adjustment of treatment intensity based on MRD.

Abstracts Discussed

Ten Year Outcomes of UKALL 2003: A Randomised Clinical Trial of Adjusting Treatment Intensity Based on Minimal Residual Disease

Samarasinghe S, Vora A, Goulden NJ, et al. Blood.2021;138(Supplement 1):364

First Results of the Risk-Adapted, MRD-Stratified GMALL Trial 08/2013 in 705 Adults with Newly Diagnosed Acute Lymphoblastic Leukemia/Lymphoma (ALL/LBL)

Goekbuget N, Stelljes M, Viardot A, et al. Blood.2021;138(Supplement 1):362

Target Audience

This education activity has been designed to meet the needs of:

• Hematologists, medical oncologists, nurse practitioners, nurses, physician assistants, pharmacists, researchers, fellows, and other HCPs interested in the treatment of patients with ALL

Directions to Learner

There are no fees for participating and receiving CME credit for this activity. During the period of June 13, 2022 through June 13, 2023, participants must:

• Read the learning objectives and faculty disclosures

• Complete the pretest

• Study the educational activity

• Complete the posttest and the evaluation form

A statement of credit will be issued only upon successful completion (75% passing score) and receipt of the activity posttest and evaluation form. Certificates will be sent via email within four weeks of receipt of a completed evaluation form.

Accreditation

Physician Continuing Education

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Integrity Continuing Education, Inc. and Bonum Continuing Education LLC.

Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
Integrity Continuing Education, Inc. designates this Other activity (multi-channel video and discussion) for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Disclosures of Conflicts of Interest

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Disclaimer

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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